2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine

Base Information

Chemical Name:2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine
CAS No.:1234572-77-0
Molecular Formula:C₁₇H₁₂FN₇O₂S
Molecular Weight:397.392
Hs Code.:

Synonyms:2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine

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Technology Process of 2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine

There total 3 articles about 2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

: 408352-74-9
2-chloro-5-nitropyrimidine-4,6-diamine

: 1234572-76-9
3-[(2-fluorophenyl)sulphanyl]-1H-indazole

: 1234572-77-0
2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In N,N-dimethyl-formamide; toluene; at 90 ℃; for 17h; Inert atmosphere;

Reference yield:

: 2557-78-0
2-fluorothiophenol

: 1234572-77-0
2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / copper(l) iodide / isopropyl alcohol; ethylene glycol / 20 h / 130 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide; toluene / 17 h / 90 °C / Inert atmosphere

With potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; XPhos; In ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 66607-27-0
3-iodoindazole

: 1234572-77-0
2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / copper(l) iodide / isopropyl alcohol; ethylene glycol / 20 h / 130 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide; toluene / 17 h / 90 °C / Inert atmosphere

With potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; XPhos; In ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;