(14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide

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Chemical Name:(14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide
CAS No.:1620083-82-0
Molecular Formula:C₂₇H₂₅ClN₄O₃
Molecular Weight:488.973
Hs Code.:

(14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide

Synonyms:(14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide

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Chemical Property of (14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide

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Technology Process of (14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide

There total 11 articles about (14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620083-81-9
(14S)-N-(4-chlorophenyl)-2-methoxy-N-methyl-16-oxo-5,6,7,13,14,15,16,17-octahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide

: 1620083-82-0
(14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide

Guidance literature:: With acetic acid; potassium iodide; at 100 ℃; for 2h;

Reference yield:

: 82278-73-7
(2S)-3-(3-bromophenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1620083-82-0
(14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: palladium diacetate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; triethylamine / N,N-dimethyl-formamide / 120 °C / Inert atmosphere; Sealed tube

3: 5% rhodium on activated aluminium oxide; hydrogen / ethyl acetate / 20 °C

4: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 24 h / 20 °C

7: potassium iodide; acetic acid / 2 h / 100 °C

With diphenyl phosphoryl azide; 5% rhodium on activated aluminium oxide; water; hydrogen; palladium diacetate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium iodide; lithium hydroxide; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 932-96-7
N-methyl(p-chloroaniline)

: 1620083-82-0
(14S)-N-(4-chlorophenyl)-N-methyl-2,16-dioxo-1,2,5,6,7,13,14,15,16,17-decahydro-12,8-(metheno)pyrido[2',3':4,5]pyrrolo[3,2-d]azacyclotetradecine-14-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: palladium diacetate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; triethylamine / N,N-dimethyl-formamide / 120 °C / Inert atmosphere; Sealed tube

3: 5% rhodium on activated aluminium oxide; hydrogen / ethyl acetate / 20 °C

4: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6: diphenyl phosphoryl azide / N,N-dimethyl-formamide / 24 h / 20 °C

7: potassium iodide; acetic acid / 2 h / 100 °C

With diphenyl phosphoryl azide; 5% rhodium on activated aluminium oxide; water; hydrogen; palladium diacetate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium iodide; lithium hydroxide; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;