(R,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(2,2,2-trifluoro-1-phenylethyl)acrylamide

Base Information

Chemical Name:(R,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(2,2,2-trifluoro-1-phenylethyl)acrylamide
CAS No.:1001088-61-4
Molecular Formula:C₁₇H₁₁BrF₃N₃O
Molecular Weight:410.193
Hs Code.:

Synonyms:(R,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(2,2,2-trifluoro-1-phenylethyl)acrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(2,2,2-trifluoro-1-phenylethyl)acrylamide

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Technology Process of (R,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(2,2,2-trifluoro-1-phenylethyl)acrylamide

There total 3 articles about (R,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(2,2,2-trifluoro-1-phenylethyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: C₁₁H₉F₃N₂O

: 1001088-61-4
(R,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(2,2,2-trifluoro-1-phenylethyl)acrylamide

Guidance literature:: With piperidine; In ethanol;
DOI:10.1016/j.bmc.2011.09.057

Reference yield:

: 22038-85-3
(R)-(-)-2,2,2-Trifluoro-1-phenylethylamine

: 1001088-61-4
(R,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(2,2,2-trifluoro-1-phenylethyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 20 °C / Neat (no solvent)

2: piperidine / ethanol

With piperidine; In ethanol; 2: Knoevenagel condensation;
DOI:10.1016/j.bmc.2011.09.057