N-[3-(4-Cyano-phenyl)-1-(piperidine-1-carbonyl)-propyl]-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-[3-(4-Cyano-phenyl)-1-(piperidine-1-carbonyl)-propyl]-4-methyl-benzenesulfonamide
CAS No.:82098-63-3
Molecular Formula:C₂₃H₂₇N₃O₃S
Molecular Weight:425.552
Hs Code.:

Synonyms:N-[3-(4-Cyano-phenyl)-1-(piperidine-1-carbonyl)-propyl]-4-methyl-benzenesulfonamide

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Chemical Property of N-[3-(4-Cyano-phenyl)-1-(piperidine-1-carbonyl)-propyl]-4-methyl-benzenesulfonamide

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Technology Process of N-[3-(4-Cyano-phenyl)-1-(piperidine-1-carbonyl)-propyl]-4-methyl-benzenesulfonamide

There total 6 articles about N-[3-(4-Cyano-phenyl)-1-(piperidine-1-carbonyl)-propyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 110-89-4
piperidine

: 82098-60-0
4-(4-Cyano-phenyl)-2-(toluene-4-sulfonylamino)-butyryl chloride

: 82098-63-3
N-[3-(4-Cyano-phenyl)-1-(piperidine-1-carbonyl)-propyl]-4-methyl-benzenesulfonamide

Guidance literature:: In benzene; Ambient temperature;

Reference yield:

: 100-27-6
2-(4-nitrophenyl)ethanol

: 82098-63-3
N-[3-(4-Cyano-phenyl)-1-(piperidine-1-carbonyl)-propyl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / H₂ / Raney-nickel / methanol / Ambient temperature

2: 1.) NaNO₂/conc. HCl; 2.) CuCN/NaCN / 1.) H₂O, 0-5 deg C; 2.) benzene, 0-5 deg C, 30 min; room temp., 4 h

3: 63 percent / PBr₃ / CHCl₃ / 1.5 h / Heating

4: 1.) KI; 2.) Na / 1.) EtOH, reflux; 2.) EtOH, reflux, 5 h

6: 52 percent / benzene / Ambient temperature

With hydrogenchloride; sodium cyanide; hydrogen; sodium; phosphorus tribromide; potassium iodide; sodium nitrite; nickel; In methanol; chloroform; benzene;

Reference yield:

: 72054-56-9
4-(2-bromoethyl)benzonitrile

: 82098-63-3
N-[3-(4-Cyano-phenyl)-1-(piperidine-1-carbonyl)-propyl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) KI; 2.) Na / 1.) EtOH, reflux; 2.) EtOH, reflux, 5 h

3: 52 percent / benzene / Ambient temperature

With sodium; potassium iodide; In benzene;