N-<2-<<<3-<<(2-amino-3-phenylpropyl)thio>carbonyl>propanoyl>thio>methyl>-3-phenylpropanoyl>glycine benzyl ester

Base Information

Chemical Name:N-<2-<<<3-<<(2-amino-3-phenylpropyl)thio>carbonyl>propanoyl>thio>methyl>-3-phenylpropanoyl>glycine benzyl ester
CAS No.:141437-93-6
Molecular Formula:C₃₂H₃₆N₂O₅S₂
Molecular Weight:592.78
Hs Code.:

Synonyms:N-<2-<<<3-<<(2-amino-3-phenylpropyl)thio>carbonyl>propanoyl>thio>methyl>-3-phenylpropanoyl>glycine benzyl ester

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Chemical Property of N-<2-<<<3-<<(2-amino-3-phenylpropyl)thio>carbonyl>propanoyl>thio>methyl>-3-phenylpropanoyl>glycine benzyl ester

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Technology Process of N-<2-<<<3-<<(2-amino-3-phenylpropyl)thio>carbonyl>propanoyl>thio>methyl>-3-phenylpropanoyl>glycine benzyl ester

There total 8 articles about N-<2-<<<3-<<(2-amino-3-phenylpropyl)thio>carbonyl>propanoyl>thio>methyl>-3-phenylpropanoyl>glycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 141437-92-5
{2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propylsulfanylcarbonyl)-propionylsulfanylmethyl]-3-phenyl-propionylamino}-acetic acid benzyl ester

: 141437-93-6
N-<2-<<<3-<<(2-amino-3-phenylpropyl)thio>carbonyl>propanoyl>thio>methyl>-3-phenylpropanoyl>glycine benzyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3.5h;
DOI:10.1021/jm00091a016

Reference yield:

: 141437-85-6,1217604-63-1
(S)-tert-butyl (1-mercapto-3-phenylpropan-2-yl)carbamate

: 141437-93-6
N-<2-<<<3-<<(2-amino-3-phenylpropyl)thio>carbonyl>propanoyl>thio>methyl>-3-phenylpropanoyl>glycine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, overnight

2: 60 percent / CF₃COOH / CH₂Cl₂ / 3.5 h / 0 - 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jm00091a016

Reference yield:

: 122818-32-0
(S)-2-<(tert-Butoxycarbonyl)amino>-3-phenylpropyl thioacetate

: 141437-93-6
N-<2-<<<3-<<(2-amino-3-phenylpropyl)thio>carbonyl>propanoyl>thio>methyl>-3-phenylpropanoyl>glycine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / 1 M NaOH / ethanol / 3 h / 0 - 20 °C

2: 80 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, overnight

3: 60 percent / CF₃COOH / CH₂Cl₂ / 3.5 h / 0 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; chloroform;
DOI:10.1021/jm00091a016