Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate

Base Information

Chemical Name:Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate
CAS No.:135253-31-5
Molecular Formula:C₂₄H₃₀O₃Si
Molecular Weight:394.586
Hs Code.:

Synonyms:Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate

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Chemical Property of Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate

Chemical Property:

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Technology Process of Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate

There total 6 articles about Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135253-30-4
Methyl <(R),(Z)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate

: 135253-31-5
Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate

Guidance literature:: With lithium thiophenoxide; In tetrahydrofuran; Yield given;
DOI:10.1246/bcsj.64.1471

Reference yield:

: 135356-01-3
(S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol

: 135253-31-5
Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate

Guidance literature:: Multi-step reaction with 4 steps

1: NEt₃, 4-dimethylaminopyridine / CH₂Cl₂

2: 95 percent / AgNO₃, N-chlorosuccinimide / acetonitrile / 0.08 h / 0 °C

3: LiN(c-Hex)2 / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 1 h

4: PhSLi / tetrahydrofuran

With dmap; N-chloro-succinimide; lithium thiophenoxide; lithium dicyclohexylamide; silver nitrate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1246/bcsj.64.1471

Reference yield:

: 135356-00-2
Methyl (S)-2,2-bis(methylthio)cyclobutane-1-carboxylate

: 135253-31-5
Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / tetrahydrofuran / 0.08 h / 0 °C

2: NEt₃, 4-dimethylaminopyridine / CH₂Cl₂

3: 95 percent / AgNO₃, N-chlorosuccinimide / acetonitrile / 0.08 h / 0 °C

4: LiN(c-Hex)2 / 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 1 h

5: PhSLi / tetrahydrofuran

With dmap; N-chloro-succinimide; lithium aluminium tetrahydride; lithium thiophenoxide; lithium dicyclohexylamide; silver nitrate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1246/bcsj.64.1471