Technology Process of methyl 5-cyano-2-(jyrimidin-2-yl)benzoate
There total 3 articles about methyl 5-cyano-2-(jyrimidin-2-yl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(diphenylphosphin)ferrocene; palladium diacetate; sodium carbonate;
In
1-methyl-pyrrolidin-2-one;
at 170 - 180 ℃;
for 3h;
Inert atmosphere;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid / dichloromethane; water / 3 h / 20 °C / Reflux
2: tetrakis(triphenylphosphine) palladium(0); cesium fluoride; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwave irradiation
3: sodium carbonate; (diphenylphosphin)ferrocene; palladium diacetate / 1-methyl-pyrrolidin-2-one / 3 h / 170 - 180 °C / Inert atmosphere; Microwave irradiation
With
(diphenylphosphin)ferrocene; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); sulfuric acid; palladium diacetate; sodium carbonate; cesium fluoride;
In
1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); cesium fluoride; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwave irradiation
2: sodium carbonate; (diphenylphosphin)ferrocene; palladium diacetate / 1-methyl-pyrrolidin-2-one / 3 h / 170 - 180 °C / Inert atmosphere; Microwave irradiation
With
(diphenylphosphin)ferrocene; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); palladium diacetate; sodium carbonate; cesium fluoride;
In
1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
