(S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Base Information

Chemical Name:(S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine
CAS No.:1623767-34-9
Molecular Formula:C₁₆H₁₅BrF₄N₂O₂
Molecular Weight:423.205
Hs Code.:

Synonyms:(S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Suppliers and Price of (S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

There total 3 articles about (S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-methyl 6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine-1-carboxylate

: 1623767-34-9
(S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Guidance literature:: (S)-methyl 6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine-1-carboxylate; With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h;

With N-Bromosuccinimide; potassium carbonate; In ethanol; N,N-dimethyl-formamide; at 20 ℃; for 25h;

Reference yield:

: (S)-methyl 3-chloro-6-(fluoromethyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine-1-carboxylate

: 1623767-34-9
(S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 130 °C / Microwave irradiation

2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

2.2: 25 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water;

Reference yield:

: 1421341-06-1
2-(3-methoxy-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1623767-34-9
(S)-1-bromo-6-(fluoromethyl)-3-(3-methoxy-4-(trifluoromethyl)phenyl)-5,6,8,9-tetrahydroimidazo[1,5-d][1,4]oxazepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 130 °C / Microwave irradiation

2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 3 h / 20 °C

2.2: 25 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water;