(RS)-tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Base Information

• Chemical Name: (RS)-tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate
• CAS No.: 1020666-32-3
• Molecular Formula: C₃₀H₃₀Cl₅N₃O₈
• Molecular Weight: 737.848

Synonyms:(RS)-tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Chemical Property of (RS)-tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

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Technology Process of (RS)-tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

There total 1 articles about (RS)-tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(4-bromomethylphenoxymethyl)-1,3-dichlorobenzene (263356-20-3) + (RS)-tert-butyl 7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-28-7) → (RS)-tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-32-3)

Guidance literature:

With sodium hydride; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jo702573z

Reference yield: 81.0%

(RS)-tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-32-3) → (RS)-tert-butyl 7-carboxymethyl-9-[4-(2,6-dichlorobenzyloxy)benzyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-36-7)

Guidance literature:

With ammonium acetate; zinc; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/jo702573z

upstream raw materials:

2-(4-bromomethylphenoxymethyl)-1,3-dichlorobenzene

(RS)-tert-butyl 7-(2,2,2-trichloroethoxycarbonylmethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Downstream raw materials:

(RS)-tert-butyl 7-carboxymethyl-9-[4-(2,6-dichlorobenzyloxy)benzyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

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