N-{3-[(allylmethylamino)methyl]-5-aminophenyl}-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-{3-[(allylmethylamino)methyl]-5-aminophenyl}-2,2,2-trifluoroacetamide
CAS No.:1354567-40-0
Molecular Formula:C₁₃H₁₆F₃N₃O
Molecular Weight:287.285
Hs Code.:

Synonyms:N-{3-[(allylmethylamino)methyl]-5-aminophenyl}-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{3-[(allylmethylamino)methyl]-5-aminophenyl}-2,2,2-trifluoroacetamide

Chemical Property:

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Technology Process of N-{3-[(allylmethylamino)methyl]-5-aminophenyl}-2,2,2-trifluoroacetamide

There total 4 articles about N-{3-[(allylmethylamino)methyl]-5-aminophenyl}-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1354567-04-6
N-{3-[(allylmethylamino)methyl]-5-nitrophenyl}-2,2,2-trifluoroacetamide

: 1354567-40-0
N-{3-[(allylmethylamino)methyl]-5-aminophenyl}-2,2,2-trifluoroacetamide

Guidance literature:: With methanol; tin(II) chloride hydrate; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm201112g

Reference yield:

: 1354566-92-9
2,2,2-trifluoro-N-(3-formyl-5-nitrophenyl)acetamide

: 1354567-40-0
N-{3-[(allylmethylamino)methyl]-5-aminophenyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

2: methanol; tin(II) chloride hydrate / dichloromethane / 0 - 20 °C

With methanol; tin(II) chloride hydrate; sodium tris(acetoxy)borohydride; In dichloromethane;
DOI:10.1021/jm201112g

Reference yield:

: 1354566-85-0
3-nitro-5-(2,2,2-trifluoroacetylamino)benzoic acid methyl ester

: 1354567-40-0
N-{3-[(allylmethylamino)methyl]-5-aminophenyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane / 1 h / Cooling

2: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

3: methanol; tin(II) chloride hydrate / dichloromethane / 0 - 20 °C

With methanol; tin(II) chloride hydrate; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/jm201112g