3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride

Base Information

• Chemical Name: 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride
• CAS No.: 1262106-83-1
• Molecular Formula: C₁₂H₁₃N₃O₃*ClH
• Molecular Weight: 283.714
• Mol file: 1262106-83-1.mol

Synonyms:3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride

Chemical Property of 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride

There total 4 articles about 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 2-{[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]carbonyl}hydrazinecarboxylate (1262106-84-2) → 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride (1262106-83-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzoic acid (1262106-81-9) → 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride (1262106-83-1)

Guidance literature:

3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzoic acid; With t-butoxycarbonylhydrazine; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; In water; ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmcl.2015.07.101

Reference yield:

5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole (1260422-02-3) → 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride (1262106-83-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / N,N-dimethyl-formamide / 130 °C

2.1: water; sodium hydroxide / butan-1-ol / Reflux

3.1: t-butoxycarbonylhydrazine; triethylamine / N,N-dimethyl-formamide / 20 °C

3.2: 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; t-butoxycarbonylhydrazine; water; triethylamine; sodium hydroxide; DavePhos; In N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1016/j.bmcl.2015.07.101

upstream raw materials:

tert-butyl 2-{[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]carbonyl}hydrazinecarboxylate

5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole

3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzoic acid

Downstream raw materials:

N'-[5-chloro-2-(4-fluorophenyl)pentanoyl]-3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide

2-[4-chloro-1-(3,4-dichlorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

2-{4-chloro-1-[4-fluoro-2-(trifluoromethyl)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

2-{4-chloro-1-[4-chloro-2-(trifluoromethyl)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole