Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester
CAS No.:361385-17-3
Molecular Formula:C₃₂H₄₅F₂N₃O₁₂
Molecular Weight:701.719
Hs Code.:

Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester

Synonyms:Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester

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Chemical Property of Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester

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Technology Process of Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester

There total 5 articles about Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-(4-amino-2-difluoromethyl-phenoxy)-tetrahydro-pyran-4-yl ester

: 361385-17-3
Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00300-6

Reference yield:

: 97-51-8
5-Nitrosalicylaldehyde

: 361385-17-3
Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 24 percent / Bu₄NBr; 5 percent aq. NaOH / CH₂Cl₂

2: 60 percent / DAST / CH₂Cl₂

3: H₂ / Pd/C / ethyl acetate

4: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / tetrahydrofuran

With sodium hydroxide; tetrabutylammomium bromide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(01)00300-6

Reference yield:

: 361385-15-1
Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-(2-formyl-4-nitro-phenoxy)-tetrahydro-pyran-4-yl ester

: 361385-17-3
Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / DAST / CH₂Cl₂

2: H₂ / Pd/C / ethyl acetate

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / tetrahydrofuran

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(01)00300-6