C₁₈H₂₈N₂O₃

Base Information

Chemical Name:C₁₈H₂₈N₂O₃
CAS No.:1402743-62-7
Molecular Formula:C₁₈H₂₈N₂O₃
Molecular Weight:320.432
Hs Code.:

C<sub>18</sub>H<sub>28</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:C₁₈H₂₈N₂O₃

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Chemical Property of C₁₈H₂₈N₂O₃

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Technology Process of C₁₈H₂₈N₂O₃

There total 2 articles about C₁₈H₂₈N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1402743-54-7
C₂₆H₃₃NO₆

: 100-46-9
benzylamine

: 1402743-62-7
C₁₈H₂₈N₂O₃

Guidance literature:: C₂₆H₃₃NO₆; With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 16h;

In toluene; for 2h; Reflux; Inert atmosphere;

benzylamine; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/anie.201203852

Reference yield:

: 317359-30-1
tert-butyl 2-methylpropylidenecarbamate

: 1402743-62-7
C₁₈H₂₈N₂O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1R,2R)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea / toluene / 24 h / -20 °C / Inert atmosphere

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 16 h / 20 °C

2.2: 2 h / Reflux; Inert atmosphere

2.3: 16 h / 20 °C / Inert atmosphere

With 5%-palladium/activated carbon; 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1R,2R)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea; hydrogen; In methanol; toluene; 1.1: Mannich reaction;
DOI:10.1002/anie.201203852