(3R,4S)-4-hydroxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidine 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

Base Information

• Chemical Name: (3R,4S)-4-hydroxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidine 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt
• CAS No.: 91814-72-1
• Molecular Formula: C₁₂H₁₄N₂O₇S*C₁₃H₂₄N₂
• Molecular Weight: 538.665
• Mol file: 91814-72-1.mol

Synonyms:(3R,4S)-4-hydroxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidine 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

Chemical Property of (3R,4S)-4-hydroxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidine 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4S)-4-hydroxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidine 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

There total 5 articles about (3R,4S)-4-hydroxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidine 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3R,4S)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt (91814-70-9) → (3R,4S)-4-hydroxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidine 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt (91814-72-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;

DOI:10.1248/cpb.32.1303

Reference yield:

3,3,6,9,9-pentamethyl-10-sulfo-2,10-diazabicyclo<4.4.0>-1-decene (87633-94-1) → (3R,4S)-4-hydroxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidine 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt (91814-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / tetrahydrofuran; dioxane / 1.5 h / 50 - 55 °C

2: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature

With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1248/cpb.32.1303

Reference yield:

(3R,4S)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone (91814-68-5) → (3R,4S)-4-hydroxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidine 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt (91814-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / tetrahydrofuran; dioxane / 1.5 h / 50 - 55 °C

2: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature

With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1248/cpb.32.1303

upstream raw materials:

(3R,4S)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

3,3,6,9,9-pentamethyl-10-sulfo-2,10-diazabicyclo<4.4.0>-1-decene

(3R,4S)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

(3R,4S)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone