Technology Process of (R)-N1-allyl-N2-Boc-N1-(o-nitrobenzenesulfonyl)-5-(triisopropylsilyloxy)pentane-1,2-diamine
There total 7 articles about (R)-N1-allyl-N2-Boc-N1-(o-nitrobenzenesulfonyl)-5-(triisopropylsilyloxy)pentane-1,2-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran; toluene;
at 20 ℃;
for 3h;
DOI:10.1039/b702649h
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / dimethylformamide
2.1: 35 g / H2 / Pd/C / ethanol
3.1: triethylamine
4.1: NaBH4 / methanol; tetrahydrofuran
5.1: triethylamine / dimethylformamide / 5 h / 20 °C
5.2: 7.00 g / DIBAL-H / tetrahydrofuran; toluene / 1 h / 0 °C
6.1: 66 percent / triphenylphosphine; DIAD / toluene; tetrahydrofuran / 3 h / 20 °C
With
sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
6.1: Mitsunobu reaction;
DOI:10.1039/b702649h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 35 g / H2 / Pd/C / ethanol
2.1: triethylamine
3.1: NaBH4 / methanol; tetrahydrofuran
4.1: triethylamine / dimethylformamide / 5 h / 20 °C
4.2: 7.00 g / DIBAL-H / tetrahydrofuran; toluene / 1 h / 0 °C
5.1: 66 percent / triphenylphosphine; DIAD / toluene; tetrahydrofuran / 3 h / 20 °C
With
sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrogen; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;
5.1: Mitsunobu reaction;
DOI:10.1039/b702649h
