(6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Base Information

Chemical Name:(6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester
CAS No.:127142-85-2
Molecular Formula:C₄₄H₄₄FN₅O₁₀S
Molecular Weight:853.925
Hs Code.:

(6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Synonyms:(6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

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Chemical Property of (6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

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Technology Process of (6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

There total 5 articles about (6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.4%

: 127142-84-1
(6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe

: 127142-85-2
(6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 3.5h;
DOI:10.1021/jm00113a026

Reference yield:

: 52312-27-3
(6R)-trans-3-(hydroxymethyl)-7-<<(1,1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenyl methyl ester

: 127142-85-2
(6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylethylamine / toluene; CH₂Cl₂ / 1.67 h / 0 - 20 °C

2: toluene; CH₂Cl₂ / 1.8 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1021/jm00113a026

Reference yield:

: C₂₇H₂₇ClN₂O₇S

: 127142-85-2
(6R)-trans-3-<<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-1-piperazinyl>carbonyl>oxy>methyl>-7-<<(1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylethylamine / toluene; CH₂Cl₂ / 3 h / Ambient temperature

2: 70.4 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 3.5 h

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00113a026