Technology Process of (R)-3-(3,4-dichlorophenyl)-1-(2-methoxyethyl)azepane
There total 6 articles about (R)-3-(3,4-dichlorophenyl)-1-(2-methoxyethyl)azepane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; potassium hydroxide;
In
acetonitrile;
at 150 ℃;
for 1h;
Microwave irradiation;
DOI:10.1021/ml300262e
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice; Reflux
2: carbonochloridic acid 1-chloro-ethyl ester / toluene / Cooling with ice; Reflux
3: water; potassium hydroxide / acetonitrile / 1 h / 150 °C / Microwave irradiation
With
lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; water; potassium hydroxide;
In
tetrahydrofuran; toluene; acetonitrile;
DOI:10.1021/ml300262e
- Guidance literature:
-
Multi-step reaction with 6 steps
1: lithium hydroxide; water / methanol / 20 - 30 °C
2: triethylamine; 2-chloro-1-methyl-pyridinium iodide / dichloromethane / 1.5 h / 20 °C
3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 1.5 h / 40 °C / Inert atmosphere
4: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice; Reflux
5: carbonochloridic acid 1-chloro-ethyl ester / toluene / Cooling with ice; Reflux
6: water; potassium hydroxide / acetonitrile / 1 h / 150 °C / Microwave irradiation
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; 2-chloro-1-methyl-pyridinium iodide; water; triethylamine; potassium hydroxide; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ml300262e
