{[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]methyl}carbamic acid benzyl ester

Base Information

Chemical Name:{[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]methyl}carbamic acid benzyl ester
CAS No.:955135-25-8
Molecular Formula:C₃₂H₄₂N₂O₆Si
Molecular Weight:578.781
Hs Code.:

Synonyms:{[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]methyl}carbamic acid benzyl ester

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Chemical Property of {[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]methyl}carbamic acid benzyl ester

Chemical Property:

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Technology Process of {[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]methyl}carbamic acid benzyl ester

There total 4 articles about {[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]methyl}carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 955135-25-8
{[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]methyl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / imidazole / dimethylformamide / 24 h

2: 99 percent / 2-iodoxybenzoic acid / ethyl acetate / 14 h / Heating

3: 63 percent / camphorsulfonic acid / methanol / 6 h / Heating

4: H₂ / Pd/C / methanol / 2 h / 25 °C / 760.05 Torr

5: 260 mg / EDCI; HOBt; (i-Pr)2NEt / CH₂Cl₂ / 12 h / 25 °C

With 1H-imidazole; camphor-10-sulfonic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo7014888

Reference yield:

: 161150-56-7
[1-(tert-butyldiphenylsilanyloxymethyl)-2-hydroxypropyl]carbamic acid benzyl ester

: 955135-25-8
{[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]methyl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 2-iodoxybenzoic acid / ethyl acetate / 14 h / Heating

2: 63 percent / camphorsulfonic acid / methanol / 6 h / Heating

3: H₂ / Pd/C / methanol / 2 h / 25 °C / 760.05 Torr

4: 260 mg / EDCI; HOBt; (i-Pr)2NEt / CH₂Cl₂ / 12 h / 25 °C

With camphor-10-sulfonic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo7014888

Reference yield:

: 161150-57-8
[1-(tert-butyldiphenylsilanyloxymethyl)-2-oxopropyl]carbamic acid benzyl ester

: 955135-25-8
{[1-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethoxypropylcarbamoyl]methyl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / camphorsulfonic acid / methanol / 6 h / Heating

2: H₂ / Pd/C / methanol / 2 h / 25 °C / 760.05 Torr

3: 260 mg / EDCI; HOBt; (i-Pr)2NEt / CH₂Cl₂ / 12 h / 25 °C

With camphor-10-sulfonic acid; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo7014888