(S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester

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Chemical Name:(S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester
CAS No.:194484-91-8
Molecular Formula:C₃₅H₅₄N₆O₁₁
Molecular Weight:734.847
Hs Code.:

(S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester

Synonyms:(S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester

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Chemical Property of (S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester

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Technology Process of (S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester

There total 11 articles about (S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2389-60-8
Z-Lys(Boc)-OH

: 194484-91-8
(S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

2: tetrahydrofuran; dimethylformamide / 6 h / -10 - 20 °C

3: 94 percent / H₂ / 10percent Pd/C / H₂O; methanol / 760 Torr / Ambient temperature

4: tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

5: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

6: 34percent aq. NH₃ / tetrahydrofuran / 2 h / -20 - 0 °C

7: 94 percent / H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature

8: tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

With 4-methyl-morpholine; ammonium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm9701132

Reference yield:

: 5545-52-8
Z-D(tBu)-OH

: 194484-91-8
(S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

2: tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

3: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

4: 34percent aq. NH₃ / tetrahydrofuran / 2 h / -20 - 0 °C

5: 94 percent / H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature

6: tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

With 4-methyl-morpholine; ammonium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9701132

Reference yield:

: C₂₄H₃₆N₂O₈

: 194484-91-8
(S)-3-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-N-[(S)-5-tert-butoxycarbonylamino-1-((S)-2-carbamoyl-pyrrolidine-1-carbonyl)-pentyl]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran; dimethylformamide / 6 h / -10 - 20 °C

2: 94 percent / H₂ / 10percent Pd/C / H₂O; methanol / 760 Torr / Ambient temperature

3: tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

4: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

5: 34percent aq. NH₃ / tetrahydrofuran / 2 h / -20 - 0 °C

6: 94 percent / H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature

7: tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

With 4-methyl-morpholine; ammonium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm9701132