sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate

Base Information

Chemical Name:sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate
CAS No.:1431772-61-0
Molecular Formula:C₂₃H₂₁N₆O₂*Na
Molecular Weight:436.449
Hs Code.:

Synonyms:sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate

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Chemical Property of sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate

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Technology Process of sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate

There total 6 articles about sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1431772-59-6
3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid

: 1431772-61-0
sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate

Guidance literature:: With water; sodium hydroxide; In water;

Reference yield:

: 1431773-70-4
methyl 3-(6-amino-5-bromopyridazin-3-yl)benzoate

: 1431772-61-0
sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / isopropyl alcohol / 40 h / 80 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

3.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 40 °C

3.2: pH 4

4.1: sodium hydroxide; water / water

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In 1,4-dioxane; water; isopropyl alcohol;

Reference yield:

: 1431772-58-5
methyl 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate

: 1431772-61-0
sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 40 °C

1.2: pH 4

2.1: sodium hydroxide; water / water

With water; sodium hydroxide; In 1,4-dioxane; water;