(S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate
CAS No.:1417654-03-5
Molecular Formula:C₂₈H₃₀I₂N₄O₅
Molecular Weight:756.379
Hs Code.:

Synonyms:(S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

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Chemical Property of (S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

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Technology Process of (S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

There total 5 articles about (S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1417654-02-4
(S)-tert-butyl (1-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)-3-((diphenoxyphosphoryl)oxy)propan-2-yl)carbamate

: 1417654-03-5
(S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

Reference yield: 46.0%

: 1417654-01-3
(S)-tert-butyl (1-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)-3-hydroxypropan-2-yl)carbamate

: 1417654-03-5
(S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

Guidance literature:: With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2013.01.022

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1417654-03-5
(S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran; 1,4-dioxane / 20 °C / Inert atmosphere; Cooling with ice

1.2: 3 h / pH 9 - 9.5

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide / toluene / 4.5 h / 20 °C / Cooling with ice

4.1: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

With lithium borohydride; chloro-trimethyl-silane; sodium azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;