1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride

Base Information

• Chemical Name: 1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride
• CAS No.: 1001398-03-3
• Molecular Formula: C₂₀H₂₄N₂O₃S*ClH
• Molecular Weight: 408.949

Synonyms:1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride

Chemical Property of 1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride

Chemical Property:

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Technology Process of 1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride

There total 1 articles about 1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate (1001397-72-3) → 1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride (1001398-03-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield: 96.0%

1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride (1001398-03-3) + 5-Bromo-2-chloropyrimidine (32779-36-5) → 4-{[1-(5-bromo-2-pyrimidinyl)-4-piperidinyl]oxy}-1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indole (1001398-11-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 48h;

Reference yield: 61.0%

1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride (1001398-03-3) + 2-chloro-5-fluoropyrimidine (62802-42-0) → 4-{[1-(5-fluoro-2-pyrimidinyl)-4-piperidinyl]oxy}-1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indole (1001398-05-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 48h;

upstream raw materials:

1,1-dimethylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

Downstream raw materials:

4-{[1-(5-fluoro-2-pyrimidinyl)-4-piperidinyl]oxy}-1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indole

1-[4-(methylsulfonyl)phenyl]-4-{[1-(5-propyl-2-pyrimidinyl)-4-piperidinyl]oxy}-2,3-dihydro-1H-indole

1-[4-(methylsulfonyl)phenyl]-4-({1-[5-(phenylmethyl)-2-pyrimidinyl]-4-piperidinyl}oxy)-2,3-dihydro-1H-indole

1-[4-(methylsulfonyl)phenyl]-4-{[1-(5-phenyl-2-pyrimidinyl)-4-piperidinyl]oxy}-2,3-dihydro-1H-indole

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