1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea

Base Information

Chemical Name:1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea
CAS No.:1349742-95-5
Molecular Formula:C₂₁H₁₈ClFN₆O
Molecular Weight:424.865
Hs Code.:

Synonyms:1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea

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Chemical Property of 1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea

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Technology Process of 1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea

There total 13 articles about 1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea trifluoroacetate

: 1349742-95-5
1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea

Guidance literature:: With ammonia; In ethyl acetate; isopropyl alcohol; at 0 ℃; for 1h;

Reference yield:

: 69395-15-9
2-(2-chloro-4-nitro-phenyl)-ethanol

: 1349742-95-5
1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

2.1: methanol / 0.25 h / 20 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: zinc; ammonium chloride / methanol / 1 h / 45 °C

6.1: N,N-dimethyl-formamide / 10 h / 75 °C

7.1: dichloromethane / 4 h / 10 °C

8.1: ammonia / ethyl acetate; isopropyl alcohol / 1 h / 0 °C

With hydrogenchloride; ammonia; ammonium chloride; Dess-Martin periodane; triethylamine; zinc; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: (2-chloro-4-nitro-phenyl)-acetic acid methyl ester

: 1349742-95-5
1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

1.2: 0.25 h

2.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

3.1: methanol / 0.25 h / 20 °C

3.2: 0 - 20 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 °C

5.1: triethylamine / dichloromethane / 1 h / 20 °C

6.1: zinc; ammonium chloride / methanol / 1 h / 45 °C

7.1: N,N-dimethyl-formamide / 10 h / 75 °C

8.1: dichloromethane / 4 h / 10 °C

9.1: ammonia / ethyl acetate; isopropyl alcohol / 1 h / 0 °C

With hydrogenchloride; lithium borohydride; ammonia; ammonium chloride; Dess-Martin periodane; triethylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;