methyl (15R)-16-benzoyloxy-12-(1-phenyl-1H-tetrazol-5-yloxy)-8,11,13-abietatrien-18-oate

Base Information

Chemical Name:methyl (15R)-16-benzoyloxy-12-(1-phenyl-1H-tetrazol-5-yloxy)-8,11,13-abietatrien-18-oate
CAS No.:122040-06-6
Molecular Formula:C₃₅H₃₈N₄O₅
Molecular Weight:594.711
Hs Code.:

Synonyms:methyl (15R)-16-benzoyloxy-12-(1-phenyl-1H-tetrazol-5-yloxy)-8,11,13-abietatrien-18-oate

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Chemical Property of methyl (15R)-16-benzoyloxy-12-(1-phenyl-1H-tetrazol-5-yloxy)-8,11,13-abietatrien-18-oate

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Technology Process of methyl (15R)-16-benzoyloxy-12-(1-phenyl-1H-tetrazol-5-yloxy)-8,11,13-abietatrien-18-oate

There total 6 articles about methyl (15R)-16-benzoyloxy-12-(1-phenyl-1H-tetrazol-5-yloxy)-8,11,13-abietatrien-18-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

: 14210-25-4
5-Chloro-1-phenyltetrazole

: 122040-05-5
methyl (16R)-16-benzoyloxy-12-hydroxy-8,11,13-abietatrien-18-oate

: 122040-06-6
methyl (15R)-16-benzoyloxy-12-(1-phenyl-1H-tetrazol-5-yloxy)-8,11,13-abietatrien-18-oate

Guidance literature:: With potassium carbonate; In butanone; for 10h; Heating;
DOI:10.1246/bcsj.61.2405

Reference yield:

: 22465-60-7
methyl abieta-8,11,13,15-tetraen-18-oate

: 122040-06-6
methyl (15R)-16-benzoyloxy-12-(1-phenyl-1H-tetrazol-5-yloxy)-8,11,13-abietatrien-18-oate

Guidance literature:: Multi-step reaction with 6 steps

1: borane-tetrahydrofuran complex / tetrahydrofuran / 1.) -10 -0 deg C, 10 min; 0-5 deg C, 3 h

2: 98.4 percent / pyridine / 1.5 h / 75 - 80 °C

3: aluminium chloride / CH₂Cl₂ / 1.) -10 deg C, 15 min; 2.) room temp., 64 h

4: 85.1 percent / m-chloroperbenzoic acid, p-toluenesulfonic acid / 1,2-dichloro-ethane / 3.5 h / Heating

5: 98.9 percent / 15percent hydrochloric acid / H₂O; ethanol / 1 h / Heating

6: 94.6 percent / potassium carbonate / butan-2-one / 10 h / Heating

With pyridine; hydrogenchloride; aluminium trichloride; borane-THF; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; butanone;
DOI:10.1246/bcsj.61.2405

Reference yield:

: 122039-83-2,122039-99-0,144969-67-5
methyl 6-hydroxy-8,11,13,15-abietatrien-18-oate

: 122040-06-6
methyl (15R)-16-benzoyloxy-12-(1-phenyl-1H-tetrazol-5-yloxy)-8,11,13-abietatrien-18-oate

Guidance literature:: Multi-step reaction with 5 steps

1: 98.4 percent / pyridine / 1.5 h / 75 - 80 °C

2: aluminium chloride / CH₂Cl₂ / 1.) -10 deg C, 15 min; 2.) room temp., 64 h

3: 85.1 percent / m-chloroperbenzoic acid, p-toluenesulfonic acid / 1,2-dichloro-ethane / 3.5 h / Heating

4: 98.9 percent / 15percent hydrochloric acid / H₂O; ethanol / 1 h / Heating

5: 94.6 percent / potassium carbonate / butan-2-one / 10 h / Heating

With pyridine; hydrogenchloride; aluminium trichloride; potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; 1,2-dichloro-ethane; butanone;
DOI:10.1246/bcsj.61.2405