N-hydroxy-11-azaartemisinin

Base Information

• Chemical Name: N-hydroxy-11-azaartemisinin
• CAS No.: 1086409-82-6
• Molecular Formula: C₁₅H₂₃NO₅
• Molecular Weight: 297.351
• Mol file: 1086409-82-6.mol

Synonyms:N-hydroxy-11-azaartemisinin

Chemical Property of N-hydroxy-11-azaartemisinin

Chemical Property:

• Melting Point: 165-167 °C
• Boiling Point: 414.6±55.0 °C(Predicted)
• PKA: 8.95±0.70(Predicted)
• Density: 1.32±0.1 g/cm3(Predicted)
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

N-Hydroxy-11-azaartemisinin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxy-11-azaartemisinin

There total 1 articles about N-hydroxy-11-azaartemisinin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

C12H13O2(CH3)3(O)(OO) (63968-64-9) → N-hydroxy-11-azaartemisinin (1086409-82-6)

Guidance literature:

C₁₂H₁₃O₂(CH₃)3(O)(OO); With hydroxylamine; In methanol; chloroform; at 0 ℃; for 1h;

With 2,6-di-tert-butylphenol; sulfuric acid; silica gel; In chloroform; water; at 20 ℃; for 12h;

DOI:10.1021/ol802238d

Reference yield: 60.0%

N-hydroxy-11-azaartemisinin (1086409-82-6) + 1-Bromo-3-phenylpropane (637-59-2) → C24H33NO5 (1086410-20-9)

Guidance literature:

N-hydroxy-11-azaartemisinin; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 2h;

1-Bromo-3-phenylpropane; In tetrahydrofuran; mineral oil; at 20 ℃; for 12h;

DOI:10.1021/ol802238d

upstream raw materials:

C₁₂H₁₃O₂(CH₃)3(O)(OO)

Downstream raw materials:

C₂₄H₃₃NO₅

Refernces

• 1、 Singh, Ajit Shankar,Verma, Ved Prakash,Hassam, Mohammad,Krishna, Naikade Niraj,Puri, Sunil K.,Singh, Chandan. "Amino- and hydroxy-functionalized 11-azaartemisinins and their derivatives". supporting information; experimental part. p. 5461 - 5464. Retrieved 2009/06/06.