2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

Base Information

Chemical Name:2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride
CAS No.:1067427-53-5
Molecular Formula:C₁₄H₁₆F₄N₂O*ClH
Molecular Weight:340.748
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

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Chemical Property of 2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

Chemical Property:

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Technology Process of 2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

There total 3 articles about 2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1208977-19-8
2,2,2-trifluoro-N-(4-fluoro-3-pyridin-4-yl-benzyl)-acetamide hydrochloride

: 1067427-53-5
2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

Guidance literature:: With hydrogen; platinum on carbon; In methanol; at 20 ℃; for 48h; under 517.162 - 3102.97 Torr;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1067427-53-5
2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 20 - 80 °C / Inert atmosphere

1.2: 0.5 h / 20 °C

2.1: hydrogen / platinum on carbon / methanol / 48 h / 20 °C / 517.16 - 3102.97 Torr

With hydrogen; sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; water; isopropyl alcohol;

Reference yield:

: 202865-68-7
3-bromo-4-fluoro-benzylamine hydrochloride

: 1067427-53-5
2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 20 - 80 °C / Inert atmosphere

1.2: 0.5 h / 20 °C

2.1: hydrogen / platinum on carbon / methanol / 48 h / 20 °C / 517.16 - 3102.97 Torr

With hydrogen; sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; water; isopropyl alcohol;