(S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1-oxopropane

Base Information

• Chemical Name: (S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1-oxopropane
• CAS No.: 159848-93-8
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 159848-93-8.mol

Synonyms:(S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1-oxopropane

Chemical Property of (S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1-oxopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1-oxopropane

There total 2 articles about (S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1-oxopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

acetaldehyde (75-07-0,9002-91-9) + N-tert-butyl 4-methoxybenzylidenecarbamate (479423-40-0) → (S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1-oxopropane (159848-93-8)

Guidance literature:

With N-(4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-2-yl)-C,C,C-trifluoro-methanesulfonamide; at 0 ℃; for 4h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/anie.200805628

Reference yield:

→ (S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1-oxopropane (159848-93-8)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; Yield given; -78 deg C then 0 deg C, 2 h;

DOI:10.1016/S0040-4020(01)85520-4

Reference yield: 86.0%

methyl (+)-(3S)-3-amino-3-(4-methoxyphenyl)propanoate (159848-76-7,227319-36-0) + (S)-3-tert-butoxycarbonylamino-3-(4-methoxyphenyl)-1-oxopropane (159848-93-8) → methyl (3S,3S')-3-<3'-tert-butoxycarbonylamino-3'-(4-methoxyphenyl)propylamino>-3-(4-methoxyphenyl)propionate (159848-94-9)

Guidance literature:

With sodium cyanoborohydride; In tetrahydrofuran; methanol; acetic acid; at 0 - 14 ℃; for 15h;

DOI:10.1016/S0040-4020(01)85520-4

upstream raw materials:

acetaldehyde

N-tert-butyl 4-methoxybenzylidenecarbamate

Downstream raw materials:

methyl (3S,3S')-3-<3'-tert-butoxycarbonylamino-3'-(4-methoxyphenyl)propylamino>-3-(4-methoxyphenyl)propionate

(3S,3S')-3--3-(4-methoxyphenyl)-1-propanol

methyl (3S,3S')-3--3-(4-methoxyphenyl)propionate

(3S,3S')-3--3-(4-methoxyphenyl)-1-(2,2,2-trichloroethoxycarbonyloxy)propane