3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride

Base Information

• Chemical Name: 3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride
• CAS No.: 2182-20-9
• Molecular Formula: C₁₈H₁₂FN₃O₆S₂
• Molecular Weight: 449.44
• Mol file: 2182-20-9.mol

Synonyms:3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride

Chemical Property of 3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride

There total 2 articles about 3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromoacetyl-benzenesulfonyl fluoride (455-82-3) → 3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride (2182-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; dioxane / Heating

In 1,4-dioxane; ethanol;

DOI:10.1021/jo01016a038

Reference yield:

3-(2-amino-thiazol-4-yl)-benzenesulfonyl fluoride (2196-70-5) + ethyl 3-oxo-3-(3-nitrophenyl)propanoate (52119-38-7) → 3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride (2182-20-9)

Guidance literature:

DOI:10.1021/jo01016a038

Reference yield:

3-{2-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride (2182-20-9) → 3-{2-[3-(3-amino-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride (2161-72-0)

Guidance literature:

With hydrogen; nickel; In 1,4-dioxane; at 80 ℃; under 77572.2 Torr;

DOI:10.1021/jo01016a038

upstream raw materials:

3-(2-amino-thiazol-4-yl)-benzenesulfonyl fluoride

ethyl 3-oxo-3-(3-nitrophenyl)propanoate

3-bromoacetyl-benzenesulfonyl fluoride

Downstream raw materials:

3-{2-[3-(3-amino-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride

3-{2-[3-(2-hexadecylsulfanyl-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride

3-{2-[3-(3-hexadecanoylamino-phenyl)-3-oxo-propionylamino]-thiazol-4-yl}-benzenesulfonyl fluoride