5-chloro-3-(3-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid

Base Information

• Chemical Name: 5-chloro-3-(3-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid
• CAS No.: 107804-62-6
• Molecular Formula: C₁₆H₉Cl₂NO₄
• Molecular Weight: 350.158

Synonyms:5-chloro-3-(3-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid

Chemical Property of 5-chloro-3-(3-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid

Chemical Property:

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Technology Process of 5-chloro-3-(3-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid

There total 6 articles about 5-chloro-3-(3-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3-chloro-α-hydroxyiminobenzyl)4,7-dichloro-2,3-dihydrobenzo[b]furan-2-carboxylic acid → 5-chloro-3-(3-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (107804-62-6)

Guidance literature:

In N-methyl-acetamide; water;

Reference yield:

4,7-Dichloro-5-{(3-chloro-phenyl)-[(Z)-hydroxyimino]-methyl}-2,3-dihydro-benzofuran-2-carboxylic acid (107804-83-1) → 5-chloro-3-(3-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (107804-62-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; Yield given; 1) 0-5 deg C -> r.t., 7h 2) r.t., overnight;

DOI:10.1248/cpb.39.1760

Reference yield:

m-Chlorobenzoyl chloride (618-46-2) → 5-chloro-3-(3-chlorophenyl)-7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (107804-62-6)

Guidance literature:

Multi-step reaction with 4 steps

1: AlCl₃ / 1,2-dichloro-ethane / 1) 0-5 deg C -> r.t., 8 h 2) r.t., overnight

2: 1N NaOH / ethanol / 2 h / Heating

3: NH₂OH*HCl, pyridine / 24 h / Heating

4: NaH / dimethylformamide / 1) 0-5 deg C -> r.t., 7h 2) r.t., overnight

With pyridine; sodium hydroxide; aluminium trichloride; hydroxylamine hydrochloride; sodium hydride; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.1760

upstream raw materials:

4,7-Dichloro-5-{(3-chloro-phenyl)-[(Z)-hydroxyimino]-methyl}-2,3-dihydro-benzofuran-2-carboxylic acid

m-Chlorobenzoyl chloride

ethyl 4,7-dichloro-2,3-dihydrobenzofuran-2-carboxylate

5-(3-chlorobenzoyl)-4,7-dichloro-2,3-dihydrobenzo[b]furan-2-carboxylic acid

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