4-fluoro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline

Base Information

Chemical Name:4-fluoro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline
CAS No.:1610610-14-4
Molecular Formula:C₂₂H₁₇F₄N₃
Molecular Weight:399.391
Hs Code.:

Synonyms:4-fluoro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline

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Chemical Property of 4-fluoro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline

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Technology Process of 4-fluoro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline

There total 6 articles about 4-fluoro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-59-6
4-fluoro-N-methylaniline

: 1610612-12-8
5-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

: 1610610-14-4
4-fluoro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline

Guidance literature:: 4-fluoro-N-methylaniline; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.166667h;

5-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 1610611-83-0
3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxylic acid

: 1610610-14-4
4-fluoro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 50 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C

3.1: phosphorus tribromide / dichloromethane / 2 h / 20 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0 °C

With thionyl chloride; sodium hexamethyldisilazane; phosphorus tribromide; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1610610-14-4
4-fluoro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(2,4-dinitrophenyl)hydroxylamine / N,N-dimethyl-formamide / 40 °C

1.2: 100 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C

3.1: phosphorus tribromide / dichloromethane / 2 h / 20 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0 °C

With sodium hexamethyldisilazane; phosphorus tribromide; diisobutylaluminium hydride; O-(2,4-dinitrophenyl)hydroxylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;