4-(benzylamino)-7-[(3,4-dimethoxyphenyl)amino]-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]pyrimidine

Base Information

• Chemical Name: 4-(benzylamino)-7-[(3,4-dimethoxyphenyl)amino]-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]pyrimidine
• CAS No.: 1345956-68-4
• Molecular Formula: C₂₄H₂₆N₆O₃
• Molecular Weight: 446.509
• Mol file: 1345956-68-4.mol

Synonyms:4-(benzylamino)-7-[(3,4-dimethoxyphenyl)amino]-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]pyrimidine

Chemical Property of 4-(benzylamino)-7-[(3,4-dimethoxyphenyl)amino]-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(benzylamino)-7-[(3,4-dimethoxyphenyl)amino]-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]pyrimidine

There total 6 articles about 4-(benzylamino)-7-[(3,4-dimethoxyphenyl)amino]-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-(benzylamino)-7-chloro-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]-pyrimidine (1345956-65-1) + 3,4-dimethoxyaniline (6315-89-5) → 4-(benzylamino)-7-[(3,4-dimethoxyphenyl)amino]-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]pyrimidine (1345956-68-4)

Guidance literature:

With palladium diacetate; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 140 ℃; for 0.833333h; regioselective reaction; Microwave irradiation;

DOI:10.1002/ejoc.201200521

Reference yield: 71.0%

→ 4-(benzylamino)-7-[(3,4-dimethoxyphenyl)amino]-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]pyrimidine (1345956-68-4)

Guidance literature:

With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 140 ℃; for 0.833333h; Microwave irradiation; Inert atmosphere;

Reference yield:

4-(benzylamino)-2,7-dichloropyrido[3,2-d]pyrimidine (1345956-64-0) → 4-(benzylamino)-7-[(3,4-dimethoxyphenyl)amino]-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]pyrimidine (1345956-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane / 12 h / Reflux

2: palladium diacetate; sodium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 0.83 h / 140 °C / Microwave irradiation

With palladium diacetate; sodium carbonate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane;

DOI:10.1002/ejoc.201200521

upstream raw materials:

4-(benzylamino)-2,7-dichloropyrido[3,2-d]pyrimidine

4-(benzylamino)-7-chloro-2-[(2-hydroxyethyl)amino]pyrido[3,2-d]-pyrimidine

3,4-dimethoxyaniline

2,4,7-trichloropyrido[3,2-d]pyrimidine