(4R,5S)-3-(benzyl)-(4-methylbenzenesulfonyloxymethyl)-4-phenyloxazolidin-2-one

Base Information

Chemical Name:(4R,5S)-3-(benzyl)-(4-methylbenzenesulfonyloxymethyl)-4-phenyloxazolidin-2-one
CAS No.:223384-33-6
Molecular Formula:C₂₄H₂₃NO₅S
Molecular Weight:437.516
Hs Code.:

Synonyms:(4R,5S)-3-(benzyl)-(4-methylbenzenesulfonyloxymethyl)-4-phenyloxazolidin-2-one

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Chemical Property of (4R,5S)-3-(benzyl)-(4-methylbenzenesulfonyloxymethyl)-4-phenyloxazolidin-2-one

Chemical Property:

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Technology Process of (4R,5S)-3-(benzyl)-(4-methylbenzenesulfonyloxymethyl)-4-phenyloxazolidin-2-one

There total 3 articles about (4R,5S)-3-(benzyl)-(4-methylbenzenesulfonyloxymethyl)-4-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 98-59-9
p-toluenesulfonyl chloride

: 223384-32-5
3-benzyl-5-hydroxymethyl-4-phenyl-(4S,5S)-1,3-oxazolan-2-one

: 223384-33-6
(4R,5S)-3-(benzyl)-(4-methylbenzenesulfonyloxymethyl)-4-phenyloxazolidin-2-one

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(99)00219-1

Reference yield:

: 93027-52-2
(+)-(2S,3S)-3-(benzylamino)-3-phenylpropane-1,2-diol

: 223384-33-6
(4R,5S)-3-(benzyl)-(4-methylbenzenesulfonyloxymethyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃ / tetrahydrofuran / 7 h / Ambient temperature

2: 85 percent / KOH / methanol / 3.5 h / Ambient temperature

3: 94 percent / Et₃N, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; potassium hydroxide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(99)00219-1

Reference yield:

: Benzyl-((1S,2S)-2,3-dihydroxy-1-phenyl-propyl)-carbamic acid methyl ester

: 223384-33-6
(4R,5S)-3-(benzyl)-(4-methylbenzenesulfonyloxymethyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / KOH / methanol / 3.5 h / Ambient temperature

2: 94 percent / Et₃N, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; potassium hydroxide; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(99)00219-1