BocD(OBzl)K(Z)POBzl

Base Information

• Chemical Name: BocD(OBzl)K(Z)POBzl
• CAS No.: 127103-16-6
• Molecular Formula: C₄₂H₅₂N₄O₁₀
• Molecular Weight: 772.896
• Mol file: 127103-16-6.mol

Synonyms:BocD(OBzl)K(Z)POBzl

Chemical Property of BocD(OBzl)K(Z)POBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of BocD(OBzl)K(Z)POBzl

There total 2 articles about BocD(OBzl)K(Z)POBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl N6-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate (68280-76-2) + (S)-3-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester (84890-97-1) → BocD(OBzl)K(Z)POBzl (127103-16-6)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at -10 - 20 ℃; for 5h; Yield given;

DOI:10.1021/jm9701132

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → BocD(OBzl)K(Z)POBzl (127103-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 5 h / -10 - 20 °C

With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm9701132

Reference yield:

BocD(OBzl)K(Z)POBzl (127103-16-6) → (S)-1-{(S)-2-[(S)-2-((R)-2-Amino-3-benzyloxy-propylamino)-3-benzyloxycarbonyl-propionylamino]-6-benzyloxycarbonylamino-hexanoyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 2 h / Ambient temperature

2: sodium cyanoborohydride, AcOH / methanol / 1 h

3: CH₂Cl₂ / 1.5 h / Ambient temperature

With sodium cyanoborohydride; acetic acid; In methanol; dichloromethane;

DOI:10.1021/jm9701132

upstream raw materials:

benzyl N⁶-((benzyloxy)carbonyl)-L-lysyl-L-prolinate trifluoroacetate

(S)-3-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester

BOC-L-aspartic acid 4-benzyl ester

Downstream raw materials:

(S)-1-{(S)-2-[(S)-2-((R)-2-Acetylamino-3-benzyloxy-propylamino)-3-benzyloxycarbonyl-propionylamino]-6-benzyloxycarbonylamino-hexanoyl}-pyrrolidine-2-carboxylic acid benzyl ester