4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one

Base Information

• Chemical Name: 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one
• CAS No.: 1357192-18-7
• Molecular Formula: C₂₆H₂₁F₄N₅O₃
• Molecular Weight: 527.478
• Mol file: 1357192-18-7.mol

Synonyms:4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one

Chemical Property of 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one

There total 3 articles about 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)propan-2-one (1357192-20-1) + 5-amino-4-fluoro-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one (1357192-22-3) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one (1357192-18-7)

Guidance literature:

5-amino-4-fluoro-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

1-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)propan-2-one; With sodium acetate; In methanol; water; at 0 ℃; for 3h;

N,N-dimethyl-formamide dimethyl acetal; In acetonitrile; at 90 ℃;

Reference yield:

1-phenylpyrazole (1126-00-7) → 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one (1357192-18-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: trifluoroacetic anhydride; dimethyl sulfoxide / tetrahydrofuran / 1.25 h / -42 - 0 °C

3.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C

3.2: 3 h / 0 °C

3.3: 90 °C

With hydrogenchloride; n-butyllithium; dimethyl sulfoxide; trifluoroacetic anhydride; sodium nitrite; In tetrahydrofuran; hexane; water;

Reference yield:

1-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-propan-2-ol (1357192-19-8) → 4-fluoro-5-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one (1357192-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic anhydride; dimethyl sulfoxide / tetrahydrofuran / 1.25 h / -42 - 0 °C

2.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C

2.2: 3 h / 0 °C

2.3: 90 °C

With hydrogenchloride; dimethyl sulfoxide; trifluoroacetic anhydride; sodium nitrite; In tetrahydrofuran; water;

upstream raw materials:

1-phenylpyrazole

1-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-propan-2-ol

1-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)propan-2-one

5-amino-4-fluoro-3,3-dimethyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-indol-2-one