5-Bromo-1-methyl-1H-pyrrole-2-carboxylicacid

Base Information

• Chemical Name: 5-Bromo-1-methyl-1H-pyrrole-2-carboxylicacid
• CAS No.: 865186-82-9
• Molecular Formula: C₆H₆BrNO₂
• Molecular Weight: 204.023
• Mol file: 865186-82-9.mol

Synonyms:5-bromo-1-methyl-1H-pyrrole-2-carboxylic acid

Chemical Property of 5-Bromo-1-methyl-1H-pyrrole-2-carboxylicacid

Chemical Property:

• Vapor Pressure: 5.65E-05mmHg at 25°C
• Boiling Point: 332.8±27.0 °C(Predicted)
• PKA: 4.32±0.41(Predicted)
• Density: 1.73±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-BROMO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Bromo-1-methyl-1H-pyrrole-2-carboxylicacid

There total 2 articles about 5-Bromo-1-methyl-1H-pyrrole-2-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Methyl-2-pyrrolecarboxylic acid (6973-60-0) → 5-bromo-1-methyl-1H-pyrrole-2-carboxylic acid (865186-82-9) + 1-methyl-4,5-dibromopyrrole-2-carboxylic acid (66067-06-9)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 - 70 ℃; for 1h;

Reference yield:

→ 5-bromo-1-methyl-1H-pyrrole-2-carboxylic acid (865186-82-9)

Guidance literature:

Reference yield:

5-bromo-1-methyl-1H-pyrrole-2-carboxylic acid (865186-82-9) + tert-butyl (2-amino-3-phenylpropyl)carbamate (943323-35-1,400652-57-5) + 1-methyl-4,5-dibromopyrrole-2-carboxylic acid (66067-06-9) → 1,1-dimethylethyl (2-{[(5-bromo-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-phenylpropyl)carbamate (1047645-24-8) + 1,1-dimethylethyl (2-{[(4,5-dibromo-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-phenylpropyl)carbamate (1047645-23-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In chloroform;

upstream raw materials:

1-Methyl-2-pyrrolecarboxylic acid

Downstream raw materials:

1,1-dimethylethyl (2-{[(5-bromo-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-phenylpropyl)carbamate

1,1-dimethylethyl (2-{[(4,5-dibromo-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-phenylpropyl)carbamate