Technology Process of (R)-(+)-1,1'-Bis(diphenylphosphino)-2,2'-bis(N,N-diisopropylamido)ferrocene, (R)-CTH-JAFAPhos
There total 1 articles about (R)-(+)-1,1'-Bis(diphenylphosphino)-2,2'-bis(N,N-diisopropylamido)ferrocene, (R)-CTH-JAFAPhos which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(-)-sparteine;
In
diethyl ether; cyclohexane;
addn. of soln. of s-BuLi in cyclohexane to a soln. of (-)-sparteine in ether at -78 °C under Ar, stirring for 10 min at -78 °C, addn. of Fe(C5H4CON(i-Pr)2)2 in ether, stirring for 2 h at -78 °C, addn. of Ph2PCl; addn. of aq. NH4Cl, extracton with CH2Cl2, concn. under reduced pressure, chromatography on silica gel deactivated with Et3N (EtOAc-hexane 1:6);
DOI:10.1139/V06-008