5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

Base Information

Chemical Name:5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole
CAS No.:114772-73-5
Molecular Formula:C₂₃H₂₆ClN₃O₂
Molecular Weight:411.931
Hs Code.:

Synonyms:5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

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Chemical Property of 5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

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Technology Process of 5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

There total 13 articles about 5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114772-72-4
5-(azidomethyl)-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole

: 114772-73-5
5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 1h; under 760 Torr; Yield given;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 114772-73-5
5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 97 percent / thionyl chloride / CHCl₃ / 4 h / 25 °C

7: sodium azide / dimethylsulfoxide / 16 h / 25 °C

8: H₂ / 10percent Pd/C / methanol / 1 h / 25 °C / 760 Torr

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; sodium azide; hydrogen; sodium methylate; acetyl chloride; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm00112a031

Reference yield:

: 624-31-7
4-tolyl iodide

: 114772-73-5
5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: 11 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 97 percent / thionyl chloride / CHCl₃ / 4 h / 25 °C

5: sodium azide / dimethylsulfoxide / 16 h / 25 °C

6: H₂ / 10percent Pd/C / methanol / 1 h / 25 °C / 760 Torr

With N-Bromosuccinimide; thionyl chloride; sodium azide; hydrogen; sodium methylate; copper; dibenzoyl peroxide; palladium on activated charcoal; In methanol; tetrachloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm00112a031