(S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,1 5-triazaheptadecan-17-oate

Base Information

Chemical Name:(S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,1 5-triazaheptadecan-17-oate
CAS No.:1404563-26-3
Molecular Formula:C₂₀H₃₇N₃O₆
Molecular Weight:415.53
Hs Code.:

Synonyms:(S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,1 5-triazaheptadecan-17-oate

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Chemical Property of (S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,1 5-triazaheptadecan-17-oate

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Technology Process of (S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,1 5-triazaheptadecan-17-oate

There total 2 articles about (S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,1 5-triazaheptadecan-17-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 39622-13-4,120746-40-9,120746-41-0
(S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride

: 1404563-26-3
(S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,1 5-triazaheptadecan-17-oate

Guidance literature:: 6-(tert-butoxycarbonylamino)hexanoic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at -20 ℃; for 0.0333333h; Inert atmosphere;

(S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at -20 - 25 ℃; for 0.166667h;

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 1404563-26-3
(S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,1 5-triazaheptadecan-17-oate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.03 h / -90 °C / Inert atmosphere

2: 4-methyl-morpholine / N,N-dimethyl-formamide; tetrahydrofuran / -20 - 25 °C

With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01632