r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane

Base Information

Chemical Name:r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane
CAS No.:866940-29-6
Molecular Formula:C₂₀H₂₄N₄O
Molecular Weight:336.437
Hs Code.:

Synonyms:r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane

Suppliers and Price of r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane

There total 6 articles about r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1122-72-1
6-methyl-2-pyridinecarboxaldehyde

: 37472-96-1
cis-3,5-diamino-trans-hydroxycyclohexane

: 866940-29-6
r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane

Guidance literature:: With triethylamine; In methanol; for 22h; Heating;
DOI:10.1039/b503606b

Reference yield:

: 866940-19-4
cis-1,3-ditosyloxy-5-(tert-butyldimethylsilanyloxy)cyclohexane

: 866940-29-6
r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / aq. HF / acetonitrile / 17 h / 40 °C

2: 87 percent / sodium azide / dimethylformamide / 16 h / 70 °C

3: 90 percent / hydrogen / Pd/C / ethanol / 18 h / 25 °C / 4500.36 Torr

4: 99 percent / triethylamine / methanol / 22 h / Heating

With sodium azide; hydrogen fluoride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b503606b

Reference yield:

: 50409-12-6,13314-30-2
cis,cis-1,3,5-trihydroxycyclohexane

: 866940-29-6
r-1-hydroxy-t-3,t-5-bis([(E)-(6-methyl-2-pyridinyl)methylene]amino)cyclohexane

Guidance literature:: Multi-step reaction with 6 steps

1: 96.7 percent / NEt₃; NaH / tetrahydrofuran / 20.5 h / 45 °C

2: 94.5 percent / pyridine / 48 h / 0 °C

3: 95 percent / aq. HF / acetonitrile / 17 h / 40 °C

4: 87 percent / sodium azide / dimethylformamide / 16 h / 70 °C

5: 90 percent / hydrogen / Pd/C / ethanol / 18 h / 25 °C / 4500.36 Torr

6: 99 percent / triethylamine / methanol / 22 h / Heating

With pyridine; sodium azide; hydrogen fluoride; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b503606b