tris<4-<2-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)ethylaminocarbonyl>butyl>isocyanurate

Base Information

• Chemical Name: tris<4-<2-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)ethylaminocarbonyl>butyl>isocyanurate
• CAS No.: 219992-98-0
• Molecular Formula: C₅₇H₆₉N₁₅O₁₂
• Molecular Weight: 1156.27
• Mol file: 219992-98-0.mol

Synonyms:tris<4-<2-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)ethylaminocarbonyl>butyl>isocyanurate

Chemical Property of tris<4-<2-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)ethylaminocarbonyl>butyl>isocyanurate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tris<4-<2-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)ethylaminocarbonyl>butyl>isocyanurate

There total 6 articles about tris<4-<2-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)ethylaminocarbonyl>butyl>isocyanurate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-yl)ethane-1,2-diamine hydrochloride + tris<(4-succinimidooxycarbonyl)butyl>isocyanurate (219992-96-8) → tris<4-<2-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)ethylaminocarbonyl>butyl>isocyanurate (219992-98-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 38 ℃; for 40h;

DOI:10.1039/a807159d

Reference yield:

Benzyl 5-bromovalerate (60343-28-4) → tris<4-<2-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)ethylaminocarbonyl>butyl>isocyanurate (219992-98-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) NaH (60 percent in oil), 2) NaI / 1) DMSO, 0 deg C then 30 min, RT, 2) DMSO, RT, 12 h

2: 93 percent / hydrogen / 10 percent Pd/C / tetrahydrofuran / 1 h

3: 100 percent / EtN=C=N(CH₂)3NMe₂*HCl / dimethylformamide; CH₂Cl₂ / 12 h / Ambient temperature

4: 80 percent / Et₃N / dimethylformamide / 40 h / 38 °C

With hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/a807159d

Reference yield:

tris<4-(benzyloxycarbonyl)butyl>isocyanurate (219992-92-4) → tris<4-<2-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-ylamino)ethylaminocarbonyl>butyl>isocyanurate (219992-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / hydrogen / 10 percent Pd/C / tetrahydrofuran / 1 h

2: 100 percent / EtN=C=N(CH₂)3NMe₂*HCl / dimethylformamide; CH₂Cl₂ / 12 h / Ambient temperature

3: 80 percent / Et₃N / dimethylformamide / 40 h / 38 °C

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/a807159d

upstream raw materials:

tris<(4-succinimidooxycarbonyl)butyl>isocyanurate

Benzyl 5-bromovalerate

1-(benzyloxy)-4-(1′,2′,4′-triazol-1′-yl)-2-(1H)-pyrimidinone

N-(1-benzyloxy-2-oxo-1,2-dihydropyrimidin-4-yl)-N'-(tert-butoxycarbonyl)ethane-1,2-diamine