2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide

Base Information

• Chemical Name: 2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide
• CAS No.: 221100-45-4
• Molecular Formula: C₂₁H₂₄INO₄S
• Molecular Weight: 513.396

Synonyms:2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide

Chemical Property of 2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide

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Technology Process of 2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide

There total 3 articles about 2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3,3-diethoxy-propyl)-2-(2-iodo-4,5-dimethoxy-phenyl)-N-(2-phenylsulfanyl-ethyl)-acetamide → 2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide (221100-45-4)

Guidance literature:

With water; toluene-4-sulfonic acid; In acetone; Yield given;

DOI:10.1016/S0040-4039(98)02550-7

Reference yield:

2-Chloroethyl phenyl sulfide (5535-49-9) → 2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide (221100-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / Na₂CO₃, NaI, Bu₄NBr / dioxane / Heating

2: NEt₃ / benzene

3: TsOH, H₂O / acetone

With tetrabutylammomium bromide; water; sodium carbonate; toluene-4-sulfonic acid; triethylamine; sodium iodide; In 1,4-dioxane; acetone; benzene;

DOI:10.1016/S0040-4039(98)02550-7

Reference yield:

(3,3-diethoxy-propyl)-(2-phenylsulfanyl-ethyl)-amine (221100-43-2) → 2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide (221100-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / benzene

2: TsOH, H₂O / acetone

With water; toluene-4-sulfonic acid; triethylamine; In acetone; benzene;

DOI:10.1016/S0040-4039(98)02550-7

upstream raw materials:

2-Chloroethyl phenyl sulfide

(3,3-diethoxy-propyl)-(2-phenylsulfanyl-ethyl)-amine

Downstream raw materials:

(E)-5-[[2-(2-Iodo-4,5-dimethoxy-phenyl)-acetyl]-(2-phenylsulfanyl-ethyl)-amino]-pent-2-enoic acid ethyl ester

(E)-5-{(2-Benzenesulfinyl-ethyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester

(E)-5-[[2-(2-Iodo-4,5-dimethoxy-phenyl)-acetyl]-((E)-2-phenylsulfanyl-vinyl)-amino]-pent-2-enoic acid ethyl ester

(Z)-5-[[2-(2-Iodo-4,5-dimethoxy-phenyl)-acetyl]-((E)-2-phenylsulfanyl-vinyl)-amino]-pent-2-enoic acid ethyl ester

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