(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(2,2-difluoroethoxy)ethoxy)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

Base Information

Chemical Name:(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(2,2-difluoroethoxy)ethoxy)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
CAS No.:1204221-55-5
Molecular Formula:C₂₃H₂₇ClF₂O₇
Molecular Weight:490.897
Hs Code.:

Synonyms:(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(2,2-difluoroethoxy)ethoxy)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

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Chemical Property of (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(2,2-difluoroethoxy)ethoxy)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

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Technology Process of (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(2,2-difluoroethoxy)ethoxy)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

There total 10 articles about (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(2,2-difluoroethoxy)ethoxy)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1118567-13-7
2-(2,2-difluoroethoxy)ethyl-4-methylbenzenesulfonate

: 1204221-17-9
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-hydroxyphenyl)methyld2)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

: 1204221-55-5
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(2,2-difluoroethoxy)ethoxy)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

: 461432-22-4
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

: 1204221-55-5
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(2,2-difluoroethoxy)ethoxy)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride; sodium borodeuteride / tetrahydrofuran / 5 - 70 °C

2.1: boron tribromide / dichloromethane / -60 - 25 °C

2.2: Cooling with ice

3.1: potassium carbonate / acetone / 20 - 75 °C

4.1: n-butyllithium / tetrahydrofuran; hexane; toluene / -78 - -70 °C

4.2: 5 h / -78 - -70 °C

4.3: 20 °C

5.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 2.5 h / -15 °C

6.1: boron tribromide / dichloromethane / -78 - 0 °C

6.2: Ice water added into reaction

7.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

With triethylsilane; aluminum (III) chloride; n-butyllithium; sodium borodeuteride; boron trifluoride diethyl etherate; boron tribromide; potassium carbonate; caesium carbonate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1204221-55-5
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(2,2-difluoroethoxy)ethoxy)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 10 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 10 h / 20 °C / Industry scale

2.1: aluminum (III) chloride / dichloromethane / -3 - 4 °C / Industry scale

3.1: triethylsilane; trifluorormethanesulfonic acid; trifluoroacetic acid / 14 h / Reflux

4.1: [D]-sodium hydroxide; tetrabutylammonium bisulfate; water-d2 / hexane; mineral oil / 24 h / 25 °C / Sealed tube

4.2: 20 °C

5.1: boron tribromide / dichloromethane / -60 - 25 °C

5.2: Cooling with ice

6.1: potassium carbonate / acetone / 20 - 75 °C

7.1: n-butyllithium / tetrahydrofuran; hexane; toluene / -78 - -70 °C

7.2: 5 h / -78 - -70 °C

7.3: 20 °C

8.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 2.5 h / -15 °C

9.1: boron tribromide / dichloromethane / -78 - 0 °C

9.2: Ice water added into reaction

10.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

With triethylsilane; aluminum (III) chloride; n-butyllithium; oxalyl dichloride; [D]-sodium hydroxide; trifluorormethanesulfonic acid; tetrabutylammonium bisulfate; boron trifluoride diethyl etherate; water-d2; boron tribromide; potassium carbonate; caesium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; mineral oil;