toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ⁵-benzo[e][1,2]oxaphosphinin-4-yl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ⁵-benzo[e][1,2]oxaphosphinin-4-yl ester
• CAS No.: 869881-95-8
• Molecular Formula: C₂₂H₁₉O₆PS
• Molecular Weight: 442.429

Synonyms:toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ⁵-benzo[e][1,2]oxaphosphinin-4-yl ester

Chemical Property of toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ⁵-benzo[e][1,2]oxaphosphinin-4-yl ester

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Technology Process of toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ⁵-benzo[e][1,2]oxaphosphinin-4-yl ester

There total 5 articles about toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ⁵-benzo[e][1,2]oxaphosphinin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methoxy-2-oxo-3-phenyl-2,3-dihydro-2λ5-benzo[e][1,2]oxaphosphinin-4-one (869881-83-4) + p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ5-benzo[e][1,2]oxaphosphinin-4-yl ester (869881-95-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 0 - 20 ℃;

DOI:10.1021/ol051871m

Reference yield:

2-(benzyl-methoxy-phosphinoyloxy)-benzoic acid methyl ester (869881-82-3) → toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ5-benzo[e][1,2]oxaphosphinin-4-yl ester (869881-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / KOH; pyridine / 3 h / 20 °C

2: 97 percent / K₂CO₃ / acetonitrile / 0 - 20 °C

With pyridine; potassium hydroxide; potassium carbonate; In acetonitrile;

DOI:10.1021/ol051871m

Reference yield:

dimethyl benzylphosphonate (773-47-7) → toluene-4-sulfonic acid 2-methoxy-2-oxo-3-phenyl-2H-2λ5-benzo[e][1,2]oxaphosphinin-4-yl ester (869881-95-8)

Guidance literature:

Multi-step reaction with 4 steps

1: phosphoryl chloride / 3 h / 60 °C

2: triethylamine / CH₂Cl₂ / 2 h / 0 - 20 °C

3: 90 percent / KOH; pyridine / 3 h / 20 °C

4: 97 percent / K₂CO₃ / acetonitrile / 0 - 20 °C

With pyridine; potassium hydroxide; potassium carbonate; triethylamine; trichlorophosphate; In dichloromethane; acetonitrile;

DOI:10.1021/ol051871m

upstream raw materials:

2-methoxy-2-oxo-3-phenyl-2,3-dihydro-2λ⁵-benzo[e][1,2]oxaphosphinin-4-one

p-toluenesulfonyl chloride

2-(benzyl-methoxy-phosphinoyloxy)-benzoic acid methyl ester

dimethyl benzylphosphonate

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