3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide

Base Information

• Chemical Name: 3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide
• CAS No.: 660440-46-0
• Molecular Formula: C₁₉H₂₃NO₃
• Molecular Weight: 313.397
• Mol file: 660440-46-0.mol

Synonyms:3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide

Chemical Property of 3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide

There total 2 articles about 3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chlorocarbonyl-1-methyl-ethyl)-benzoic acid ethyl ester → 3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide (660440-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 - 25 °C

2: 90 percent / LiBH₄ / methanol; tetrahydrofuran

With lithium borohydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.08.044

Reference yield:

3-(p-carbetoxyphenyl)butyric acid (102152-63-6,102152-64-7,102152-65-8) → 3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide (660440-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (COCl)2 / 0 °C

2: Et₃N / CH₂Cl₂ / 0 - 25 °C

3: 90 percent / LiBH₄ / methanol; tetrahydrofuran

With lithium borohydride; oxalyl dichloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.08.044

Reference yield: 94.0%

3-(R)-(4-hydroxymethylphenyl)-N-((S)-2-hydroxy-1-phenylethyl)-butyramide (660440-46-0) → 3-(4-hydroxymethyl-phenyl)-butyric acid (926009-93-0)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; Heating;

DOI:10.1016/j.bmcl.2006.08.044

upstream raw materials:

3-(p-carbetoxyphenyl)butyric acid

Downstream raw materials:

3-(4-hydroxymethyl-phenyl)-butyric acid

(R)-(-)-3-(4-hydroxymethylphenyl)butyric acid methyl ester

(R)-3-(4-methanesulfonyloxymethylphenyl)butyric acid methyl ester

3-(4-{3-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-2-oxo-2H-pyridin-1-ylmethyl}-phenyl)-butyric acid methyl ester