(E)-butyl 3-{4-phenoxy-2-(p-tolylthiomethyl)phenyl}acrylate

Base Information

• Chemical Name: (E)-butyl 3-{4-phenoxy-2-(p-tolylthiomethyl)phenyl}acrylate
• CAS No.: 1372783-86-2
• Molecular Formula: C₂₇H₂₈O₃S
• Molecular Weight: 432.584
• Mol file: 1372783-86-2.mol

Synonyms:(E)-butyl 3-{4-phenoxy-2-(p-tolylthiomethyl)phenyl}acrylate

Chemical Property of (E)-butyl 3-{4-phenoxy-2-(p-tolylthiomethyl)phenyl}acrylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-butyl 3-{4-phenoxy-2-(p-tolylthiomethyl)phenyl}acrylate

There total 2 articles about (E)-butyl 3-{4-phenoxy-2-(p-tolylthiomethyl)phenyl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

acrylic acid n-butyl ester (141-32-2,9003-49-0) + (3-phenoxybenzyl)(p-tolyl)sulfane (1372783-75-9) → (E)-butyl 3-{4-phenoxy-2-(p-tolylthiomethyl)phenyl}acrylate (1372783-86-2)

Guidance literature:

With palladium diacetate; silver trifluoroacetate; In 1,2-dichloro-ethane; at 100 ℃; for 12h; regioselective reaction;

DOI:10.1021/ol3006997

Reference yield:

3-phenoxybenzyl bromide (51632-16-7) + para-thiocresol (106-45-6) → (E)-butyl 3-{4-phenoxy-2-(p-tolylthiomethyl)phenyl}acrylate (1372783-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2: palladium diacetate; silver trifluoroacetate / 1,2-dichloro-ethane / 12 h / 100 °C

With palladium diacetate; silver trifluoroacetate; potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/ol3006997

upstream raw materials:

acrylic acid n-butyl ester

(3-phenoxybenzyl)(p-tolyl)sulfane

3-phenoxybenzyl bromide

para-thiocresol