(R,R)-(-)-1,2-DIAMINOCYCLOHEXANE HYDROCHLORIDE

Base Information

• Chemical Name: (R,R)-(-)-1,2-DIAMINOCYCLOHEXANE HYDROCHLORIDE
• CAS No.: 191480-63-4
• Molecular Formula: C6H14 N2 . Cl H
• Molecular Weight: 150.651
• Mol file: 191480-63-4.mol

Synonyms:1,2-Cyclohexanediamine,monohydrochloride, (1R,2R)- (9CI); 1,2-Cyclohexanediamine, monohydrochloride, (1R-trans)-;(1R,2R)-1,2-Cyclohexanediamine monohydrochloride;(1R,2R)-1,2-Diaminocyclohexane monohydrochloride; (1R,2R)-Diaminocyclohexanemonohydrochloride

Chemical Property of (R,R)-(-)-1,2-DIAMINOCYCLOHEXANE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.46mmHg at 25°C
• Boiling Point: 193.6°C at 760 mmHg
• Flash Point: 75°C
• PSA: 52.04000
• LogP: 2.41760

Purity/Quality:

99% ^*data from raw suppliers

(1R,2R)-Cyclohexane-1,2-diaminehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R,R)-(-)-1,2-DIAMINOCYCLOHEXANE HYDROCHLORIDE

There total 1 articles about (R,R)-(-)-1,2-DIAMINOCYCLOHEXANE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → (1R,2R)-1,2-diaminocyclohexane monohydrochloride (191480-63-4)

Guidance literature:

With hydrogenchloride; In diethyl ether;

Reference yield: 100.0%

(1R,2R)-1,2-diaminocyclohexane monohydrochloride (191480-63-4) + 3-(tert-butyl)-2-hydroxy-5-(pyridin-4-yl)benzaldehyde (342037-22-3) → C22H29N3O*ClH (1448984-96-0)

Guidance literature:

In methanol; at 60 ℃; for 4h;

DOI:10.1039/c3cc43225d

Reference yield: 99.0%

(1R,2R)-1,2-diaminocyclohexane monohydrochloride (191480-63-4) + 2,5-hexanedione (110-13-4) → (1R,2R)-2-(2,5-dimethyl-1H-pyrrol-1-yl)cyclohexan-1-amine (764650-90-0)

Guidance literature:

With acetic acid; In methanol; at 50 ℃;

DOI:10.1021/acs.orglett.0c02629

upstream raw materials:

(1R,2R)-1,2-diaminocyclohexane

Refernces

• 1、 Maleev, Victor I.,Chusov, Denis A.,Yashkina, Lidiya V.,Ikonnikov, Nikolai S.,Il'In, Michail M.. "Asymmetric ring opening of epoxides with cyanides catalysed by chiral binuclear titanium complexes". . p. 838 - 843. Retrieved 2014/06/23.
• 2、 Zhang, Zhiguo,Lippert, Katharina M.,Hausmann, Heike,Kotke, Mike,Schreiner, Peter R.. "Cooperative thiourea-Bronsted acid organocatalysis: Enantioselective cyanosilylation of aldehydes with TMSCN". experimental part. p. 9764 - 9776. Retrieved 2012/01/03.