3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid

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Chemical Name:3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid
CAS No.:851047-02-4
Molecular Formula:C₂₂H₂₄N₆O₆
Molecular Weight:468.469
Hs Code.:

Synonyms:3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid

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Chemical Property of 3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid

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Technology Process of 3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid

There total 7 articles about 3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 851047-01-3
3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid methyl ester

: 851047-02-4
3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid

Guidance literature:: 3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid methyl ester; With sodium hydroxide; water; In methanol; at 20 ℃;

With acetic acid; In water;

Reference yield:

: C₂₉H₄₂N₆O₅Si

: 851047-02-4
3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

2.2: 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: sodium hydroxide; water / methanol / 20 °C

With sodium hydroxide; tetrabutyl ammonium fluoride; water; hydrogen; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dimethyl sulfoxide;

Reference yield:

: 1-[9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-3-phenyl-urea

: 851047-02-4
3-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

1.2: 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: sodium hydroxide; water / methanol / 20 °C

With sodium hydroxide; water; hydrogen; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide;