((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone

Base Information

Chemical Name:((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone
CAS No.:1445590-90-8
Molecular Formula:C₂₀H₂₃BrClN₃O₂
Molecular Weight:452.779
Hs Code.:

Synonyms:((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone

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Chemical Property of ((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone

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Technology Process of ((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone

There total 14 articles about ((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1445590-77-1
((R)-3-methylmorpholino)((1R,2R)-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)methanone

: 1445590-90-8
((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone

Guidance literature:: With N-chloro-succinimide; In acetonitrile; Reflux;

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 1445590-90-8
((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone

Guidance literature:: Multi-step reaction with 10 steps

1.1: bromine / chloroform / 0 - 20 °C

1.2: 6 h / 0 °C

1.3: pH 5

2.1: acetic anhydride / 20 h / Reflux

3.1: quinine / toluene; tetrachloromethane / 60 h / -65 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

5.1: acetonitrile / 5 h / 20 °C / Inert atmosphere

6.1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

7.1: hydrogenchloride / water / 2 h / 80 °C

8.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 2 h / 0 - 20 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

10.1: N-chloro-succinimide / acetonitrile / Reflux

With hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; bromine; potassium acetate; acetic anhydride; quinine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; chloroform; water; toluene; acetonitrile;

Reference yield:

: 1461-96-7
cis-1,2-cyclopentanedicarboxylic acid

: 1445590-90-8
((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone

Guidance literature:: Multi-step reaction with 9 steps

1: acetic anhydride / 20 h / Reflux

2: quinine / toluene; tetrachloromethane / 60 h / -65 °C

3: lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

4: acetonitrile / 5 h / 20 °C / Inert atmosphere

5: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

6: hydrogenchloride / water / 2 h / 80 °C

7: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 2 h / 0 - 20 °C

8: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

9: N-chloro-succinimide / acetonitrile / Reflux

With hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium acetate; acetic anhydride; quinine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water; toluene; acetonitrile;