N-{5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

Base Information

Chemical Name:N-{5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide
CAS No.:1621694-34-5
Molecular Formula:C₃₇H₃₇Cl₂N₅O
Molecular Weight:638.64
Hs Code.:

Synonyms:N-{5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

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Chemical Property of N-{5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

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Technology Process of N-{5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

There total 2 articles about N-{5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 827601-89-8
N¹-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)pentane-1,5-diamine

: 1567847-47-5
C₂₄H₂₃ClN₂O₄*ClH

: 1621694-34-5
N-{5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

: 1621694-42-5
C₄₂H₄₅Cl₂N₅O₃

Guidance literature:: C₂₄H₂₃ClN₂O₄*ClH; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; In ethyl acetate; at 20 ℃; for 0.0833333h;

N¹-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)pentane-1,5-diamine; at 20 ℃; for 18h;
DOI:10.1016/j.ejmech.2014.07.021

Reference yield:

: 1567847-49-7
ethyl 1-(tert-butoxycarbonyl)-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxylate

: 1621694-34-5
N-{5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

: 1621694-42-5
C₄₂H₄₅Cl₂N₅O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 24 h / Reflux

1.2: 0.5 h

2.1: N,N-dimethyl-formamide; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / ethyl acetate / 0.08 h / 20 °C

2.2: 18 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In methanol; ethyl acetate;
DOI:10.1016/j.ejmech.2014.07.021