1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano

Base Information

• Chemical Name: 1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano
• CAS No.: 934755-04-1
• Molecular Formula: C₃₈H₅₆N₄O₈
• Molecular Weight: 696.885
• Mol file: 934755-04-1.mol

Synonyms:1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano

Chemical Property of 1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano

There total 6 articles about 1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

(7-Benzyloxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid benzyl ester (871544-37-5) + bromoacetic acid tert-butyl ester (5292-43-3) → 1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano (934755-04-1)

Guidance literature:

With potassium carbonate; In acetonitrile;

DOI:10.1016/j.bmc.2009.05.041

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + 4,10-(benzyloxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane → 1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano (934755-04-1)

Guidance literature:

With potassium carbonate; In acetonitrile;

Reference yield:

1,4,7,10-tetraazacyclododecan (294-90-6) → 1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano (934755-04-1)

Guidance literature:

Multi-step reaction with 4 steps

1: chloroform / 48 h / 20 °C

2: potassium carbonate / acetonitrile / Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4: potassium carbonate / acetonitrile / Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; chloroform; acetonitrile;

upstream raw materials:

(7-Benzyloxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid benzyl ester

bromoacetic acid tert-butyl ester

1,4,7,10-tetraaza-cyclododecane-1,7-dicarboxylic acid dibenzyl ester

1,4,7,10-tetraazacyclododecan